2-Phenylacetamide/Phenylacetamide CAS 103-81-1
- YANXI
- Hebei,china
- 3-5 days
- 30ton / Month
2-Phenylacetamide is an endogenous metabolite.White flake crystal. Soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene. 2-Phenylacetamide is used as an intermediate in drugs such as penicillin G .
1.production methodprocess ：
The styrene, sulfur, liquid ammonia and water were put into the autoclave, and the reaction was carried out at 165℃ and about 6.5MPa under pressure. Then, the hydrogen sulfide gas was heated and evaporated, and the activated carbon was added for decolorization, cooling, crystallization, filtration and drying to obtain acetamide. This method can be improved to pipelined continuous production, styrene and ammonium polysulfide liquid according to the volume ratio of 1:2, through the high pressure pipeline, reaction temperature of 200℃, reaction pressure of 6-7.8MPa, reaction time of 1.5h. The post-treatment process of reaction products is similar to that of autoclave batch method. Raw material consumption quota: styrene (99%)1117kg/t, sulfur (98.5%)716kg/t, liquid ammonia (99%)539kg/t, activated carbon 47kg/t. Another method of production is to hydrolyze acetonitrile (obtained by the reaction of benzyl chloride and sodium cyanide in an aqueous solution of dimethylamine) by heating in sulfuric or hydrochloric acid. Add acetonitrile to concentrated hydrochloric acid, stir to dissolve, reaction at 50℃ for half an hour. Then slowly add water to precipitate crystallization under cooling, after cooling, filter, wash with ice water to obtain coarse product. The crude product is washed with sodium carbonate solution, and then washed with ice water. After drying, more pure acetamide can be obtained. Raw material consumption quota: Benzyl chloride (95%)1190kg/t, sodium cyanide (95%)527kg/t, dimethylamine (industrial product)20kg/t, sodium carbonate (industrial product)185kg/t, sulfuric acid (92.5%)1760kg/t.
2.application：
Used as an intermediate in drugs such as penicillin and phenobarbital. It is also used for the preparation of phenylacetic acid, spices and pesticides
3.Basic Info.
| Chemical Name | 2-phenylacetamide | ||
| Synonyms | Phenylacetamide;α-Toluamide;Acetamide,2-phenyl;Ph-CH2-CO-NH2;2-PhenylacetaMide;2-phenyl-acetamide;Benzeneacetamide; | ||
| CAS NO. | 103-81-1 | Purity | 99% |
| Appearance | Powder | Application | Pharmaceutical intermediates |
| Molecular Formula | C8H9NO | Molecuar Weight | 135.16300 |
| Boiling Point | 280-290 °C (dec.) | Melting Point | 156 °C |
| PSA | 43.09000 | LOGP | 1.41470 |
| Storage Condition | Keep in a cool and dry place |
| Production Capacity | 10tons/month |
| MOQ | 1kg |
| Packaging | 1kg/bottle, 25kg drum |
| Transportation | By Sea or by Air(DHL/UPS/TNT/FEDEX/EMS) |
| Port | Tianjin, Shanghai or any port in China |
| Delivery Time | 5-15 days |
| Payment | T/T, Western Union or Bitcoin |
4.product details：
5.Our advantage:
1) Most products on stock, ship out within 1-3 days !
2) Products are tested by QC department strictly before shipping !
3) Make sure the part's safety with our strong shipping line !
4) Customs pass and satisfied rate ≥99% !
5) Responsible for all after-sale quality issues
We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.
We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.
